Working Principle of Hyaluronic Acid Pre-filled Syringe Filling Machine

1. Feeding & Positioning

• Syringe feeding: Pre-sterilized empty syringes are oriented by robotic arms, conveyed via belt system to workstations, with positioning clamps ensuring ±0.1mm accuracy.

• HA supply: Sterile hyaluronic acid solution is stored in sealed containers, delivered through tubing (optionally with temperature control to prevent gelation).

2. Filling Phase

• Precision dosing:

• Piston pumps achieve ±1% volumetric accuracy for consistent fill volumes.

• Non-contact filling needles eliminate cross-contamination risks.

• Negative pressure environment minimizes bubble formation.

3. Sealing & Assembly

• Stopper placement: Robotic arms insert sterile rubber stoppers with vacuum-assisted alignment.

• Headspace nitrogenation (optional): N₂ purging before stoppering extends shelf life.

• Integrity check (optional): Vision systems verify stopper seating.

4. Labeling & Traceability

• Laser marking/label printers apply batch numbers and expiry dates, with data auto-uploaded to MES.

5. Packaging & Output

• Nesting (optional): Auto-arrangement into blister trays.

• Secondary packaging (optional): Integrated cartoning, shrink-wrapping, and anti-tamper labeling systems.

Key Technical Features

• Cleanroom compliance: Localized ISO Class 5 (Grade A) environment with laminar flow hoods.

• Material compatibility: Medical-grade stainless steel/polymer fluid paths prevent HA adsorption.

• CIP/SIP capability: Advanced models support clean-in-place/sterilize-in-place for inter-batch decontamination.